Copper-catalyzed trifluoromethylation of alkenes: synthesis of trifluoromethylated benzoxazines.
نویسندگان
چکیده
A simple base and ligand free copper catalyzed method for the construction of trifluoromethylated benzoxazines has been developed by using Umemoto's reagent. It involves the oxidative difunctionalization of alkenes through tandem C-O and C-CF3 bond formations. Furthermore, synthesized benzoxazines were selectively converted into trifluoromethylated allylic and (E)-vinylic benzamides by the treatment of KO(t)Bu and CH3Li, respectively.
منابع مشابه
Copper-catalyzed trifluoromethylation of alkenes with an electrophilic trifluoromethylating reagent
An efficient method for the copper-catalyzed trifluoromethylation of terminal alkenes with an electrophilic trifluoromethylating reagent has been developed. The reactions proceeded smoothly to give trifluoromethylated alkenes in good to excellent yields. The results provided a versatile approach for the construction of Cvinyl-CF3 bonds without using prefunctionalized substrates.
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ورودعنوان ژورنال:
- Organic & biomolecular chemistry
دوره 13 31 شماره
صفحات -
تاریخ انتشار 2015